Cyclopentanoic acid methyl ester

Cyclopentanoic acid methyl ester - Names and Identifiers

Name	Methyl cyclopentanecarboxylate
Synonyms	NSC 87553 RARECHEM AL BF 0721 Methyl cyclopentanecarboxylate METHYL CYCLOPENTANECARBOXYLATE Methyl cyclopentane carboxylate Cyclopentanoic acid methyl ester Cyclopentanecarboxylic acid methyl Cyclopentanecarboxylic acid methyl ester Cyclopentane-1-carboxylic acid methyl ester
CAS	4630-80-2
EINECS	225-049-7
InChI	InChI=1/C7H12O2/c1-9-7(8)6-4-2-3-5-6/h6H,2-5H2,1H3

Cyclopentanoic acid methyl ester - Physico-chemical Properties

Molecular Formula	C7H12O2
Molar Mass	128.17
Density	1.014
Melting Point	77-78℃
Boling Point	81-82°C 5mm
Flash Point	81-82°C/5mm
Solubility	Difficult to mix.
Vapor Presure	2.55mmHg at 25°C
Appearance	clear liquid
Color	Colorless to Almost colorless
BRN	2040762
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.4360
MDL	MFCD00019290

Cyclopentanoic acid methyl ester - Risk and Safety

Safety Description	24/25 - Avoid contact with skin and eyes.
UN IDs	UN 3272 3/PG III
Hazard Class	IRRITANT
Packing Group	III

Cyclopentanoic acid methyl ester - Reference Information

Introduction

Methyl cyclopentane formate is an important pharmaceutical intermediate, such as it can be used to prepare ruzolitinib.

preparation

preparation of methyl cyclopentanecarboxylate: at 25°C, to cyclopentanecarboxylic acid (5.0g,43.8mmol) dichloromethane (30mL) and methanol (10mL) solution Add (trimethylsilyl) diazomethane (2.0M hexane solution, 109mL,219.0mmol). After adding, the solution was stirred at 25°C for 2h, and then concentrated under reduced pressure to obtain methyl cyclopentane formate (5g,89%), which was a yellow oil.

Last Update：2024-04-09 02:00:08